(dGEMRIC) has been shown to be a clinically useful tool for assessing the glycosaminoglycan (GAG) content in cartilage (1–4). Proteoglycans (PGs) are major contrib-utors to the compressive stiffness of cartilage, and are lost in the early stages of osteoarthritis (5). The dGEM-RIC technique measures the T1 relaxation time of car-

Up to the levels of AF and NP, this is reproducible in MRI in dGEMRIC technique, but not in X-ray or standard MRI sequences. Potentially, the MRI in dGEMRIC technique can be used as a non-invasive in vivo indicator for disc degeneration in the cervical spine. Copyright © 2016 Elsevier Inc. All rights reserved. PMID: 27568543 [Indexed for MEDLINE]

The dGEMRIC effect depends on the use of a charged gadolinium contrast agent. A non-ionic contrast agent will not be able … Noninvasive techniques are needed for the assessment of the repair tissue. HYPOTHESIS: Magnetic resonance imaging (MRI) with delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) can give valuable information regarding the quality and quantity of the repaired cartilage lesion. STUDY DESIGN: Cohort study; Level of evidence, 3. 2006-11-01 According to the decrease of glycosaminoglycans in cartilage degeneration, more Gd-DTPA2 penetrates into the cartilage, which will cause a reduction of T1 relaxation time that can be measured in milliseconds - "Current knowledge and importance of dGEMRIC techniques in diagnosis of hip joint diseases" The dGEMRIC technique used in this study had already been applied in previous studies [16, 21]. In a study on 30 patients after MACT, with a mean follow-up of 19.61 ± 8.81 months, Trattnig et al. found a mean T1 RT of 427 ± 159 ms and a mean T1 RC of 636 ± 189 ms.

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2015-04-26 · Hence, the dGEMRIC technique holds promise for the development of new diagnostic and therapeutic procedures. However, because of the location of the hip joint deep within the body and due to the fairly thin cartilage layers that require high spatial resolution, the diagnosis of early hip joint cartilage alterations may be problematic. Background dGEMRIC (delayed Gadolinium Enhanced Magnetic Resonance Image of Cartilage) is a well-established technique for cartilage quality assessment in osteoarthritis at clinical field strengths. The method is robust, but requires injection of contrast agent and a cumbersome examination procedure. New non-contrast-agent-based techniques for cartilage quality assessment are currently being dGEMRIC studies have so far been conducted at clinical field strengths. To enable the use of dGEM-RIC as a reference tool during the development of the new techniques, there is a need to first validate dGEMRIC also at 7 T. Translating the dGEMRIC technique to an ultra-high field strength may have some advantages but there are also several Contrast-enhanced MRI of human knee cartilage Clinical applications of the novel dGEMRIC technique to study glycosaminoglycan content in articular cartilage Tiderius, Carl Johan L Contrast-enhanced MRI of human knee cartilage Clinical applications of the novel dGEMRIC technique to study glycosaminoglycan content in articular cartilage. / Tiderius, Carl Johan.

dGEMRIC (delayed Gadolinium Enhanced Magnetic Resonance Image of Cartilage) is a well-established technique for cartilage quality assessment in osteoarthritis at clinical field strengths. The method is robust, but requires injection of contrast agent and a cumbersome examination procedure.

Conversely, if Gd-DTPA 2-is present in the hyaline cartilage, concentration can be assumed to be in regions 2006-01-01 2013-09-25 To determine the feasibility of using a high resolution isotropic three‐dimensional (3D) fast T1 mapping sequence for delayed gadolinium‐enhanced MRI of cartilage (dGEMRIC) to assess osteoarthritis in 2016-02-11 2011-06-29 dGEMRIC, or delayed gadolinium-enhanced MRI of cartilage is a technique that can be used quantitatively to assess glycosaminoglycan content of cartilage or qualitatively to asses the overall structures of cartilage. When the technique is adapted and applied to menisci it is called dGEMRIM. Delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) is sensitive to the glycosaminoglycan content in cartilage that is lost early in the development of osteoarthritis (OA).

Will be measured using the delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) technique Lumbar lordosis angle [ Time Frame: Baseline: before surgery ] Will be measured by the EOS imaging system.

Three-dimensional T1 quantification techniques  The dGEMRIC MRI requires an injection of a contrast agent, while the T1-rho MRI does not. If the T1-rho is shown to be as useful as the dGEMRIC method it can  LIBRIS titelinformation: Contrast-enhanced MRI of human knee cartilage : clinical applications of the novel dGEMRIC technique to study glycosaminoglycan  SwePub titelinformation: Contrast-enhanced MRI of human knee cartilage Clinical applications of the novel dGEMRIC technique to study glycosaminoglycan  Delayed gadolinium‐enhanced MRI of cartilage (dGEMRIC) in early knee for determination of absorbed dose distributions using MRI technique: basic studies. Delayed gadolinium-enhanced. MRI of cartilage (dGEMRIC) is a previously presented method for identification of early OA using magnetic resonance imaging  The delayed gadolinium enhanced MRI of cartilage (dGEMRIC) technique is the only non-invasive means to estimate proteoglycan (PG) content in articular  MR/CT workflow to enable clinical implementation of the technique. work was to establish dGEMRIC as a method at 7 T by a field strength.

We tested two strategies to reduce metal artifact in dGEMRIC: (1) saturation recovery (SR) instead of inversion recovery (IR) and (2) applying the metal artifact reduction sequence (MARS), in a gadolinium-doped agarose gel phantom and in vivo with titanium hardware. These preliminary results suggest that the dGEMRIC technique may be able to detect change in proteoglycan content in knee cartilage among individuals taking collagen hydrolysate after 24 weeks. The most straightforward application of dGEMRIC or any molecular imaging technique is simply to demonstrate and follow “lesions” in otherwise apparently normal-appearing cartilage. Detection and monitoring of these lesions demonstrate a number of paradigm-changing concepts in the evaluation of cartilage physiology and pathophysiology.
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Fast T1 mapping techniques such as the Look-Locker (15) and DESPOT (16) techniques are available. 2016-10-05 2013-09-25 Purpose To determine the feasibility of using a high resolution isotropic three‐dimensional (3D) fast T1 mapping sequence for delayed gadolinium‐enhanced MRI of cartilage (dGEMRIC) to assess osteoarthritis in the hip.

Materials and methods. We examined the effect of stainless-steel and titanium hardware on dGEMRIC T 1 maps. We tested two strategies to reduce metal artifact in dGEMRIC: (1) saturation recovery (SR) instead of inversion recovery (IR) and (2) applying the metal artifact reduction sequence (MARS), in a gadolinium-doped agarose gel phantom and in vivo with titanium hardware. The dGEMRIC technique is a potentially useful clinical imaging method that is currently limited by the long imaging time and need for post‐processing.
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2020-04-01

Mark; Abstract Accurate assessment of early hip joint cartilage alterations may help optimize patient selection and follow-up of hip joint preservation surgery. To determine whether either of two magnetic resonance imaging approaches - delayed gadolinium enhanced magnetic resonance imaging of cartilage (dGEMRIC), or T2 mapping - can detect short-term changes in knee hyaline cartilage among individuals taking a formulation of collagen hydrolysate.

dGEMRIC technique uses either a two-dimensional (2D) or 3D spin-echo inversion recovery or saturation recovery sequence with varying inversion time (TI) or repetition time (TR). These series of images are then post-processed to obtain the T1 maps (14). Fast T1 mapping techniques such as the Look-Locker (15) and DESPOT (16) techniques are available.

The 3D Look-Locker technique has been validated against the traditional inversion recovery technique. DELAYED GADOLINIUM‐ENHANCED MRI of cartilage (dGEMRIC) is known to be a reliable technique for evaluating the glycosaminoglycan (GAG) concentration of articular cartilage (1, 2). GAGs have side groups that confer a negative charge to the cartilage matrix.

dGEMRIC using the Look-Locker technique, Carl Siversson et al, Abstract and oral presentation at International Society for Magnetic Resonance in Medicine (ISMRM) meeting 2008, Toronto, Canada, no 5289 B1 inhomogeneity corrected T1-quantification for dGEMRIC using 3D Look- dGEMRIC (delayed Gadolinium Enhanced Magnetic Resonance Image of Cartilage) is a well-established technique for cartilage quality assessment in osteoarthritis at clinical field strengths. The method is robust, but requires injection of contrast agent and a cumbersome examination procedure. The most straightforward application of dGEMRIC or any molecular imaging technique is simply to demonstrate and follow “lesions” in otherwise apparently normal-appearing cartilage. Detection and monitoring of these lesions demonstrate a number of paradigm-changing concepts in the evaluation of cartilage physiology and pathophysiology. To determine the feasibility of using a high resolution isotropic three‐dimensional (3D) fast T1 mapping sequence for delayed gadolinium‐enhanced MRI of cartilage (dGEMRIC) to assess osteoarthritis in dGEMRIC technique uses either a two-dimensional (2D) or 3D spin-echo inversion recovery or saturation recovery sequence with varying inversion time (TI) or repetition time (TR).